Synthesis of both enantiomers of C2 symmetric trans-2,5- bis(hydroxymethyl)pyrrolidine. Lipase mediated sequential kinetic resolutions

DOI: 10.1016/S0040-4039(00)73281-3

Source and publish data:

Tetrahedron Letters p. 4915 - 4918 (1994)

Update date:2022-08-05

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Authors:

Sibi Sibi

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Article abstract of DOI:10.1016/S0040-4039(00)73281-3

Lipase mediated sequential kinetic resolution has been employed to give both enantiomers of trans-2,5-bis(hydroxymethyl)pyrrolidine in optically pure form. The effect of different parameters on the ee and yields in these resolutions are also reported.

Full text of DOI:10.1016/S0040-4039(00)73281-3

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