Monatshefte fur Chemie p. 559 - 576 (1993)
Update date:2022-07-29
Topics:
Draeger, M.
Haber, M.
Erfanian-Abdoust, H.
Pindur, U.
Sattler, Kristin
1-Alkylpyrano<3,4-b>indol-3-ones 3 react via a Diels-Alder step with an aryne or N-phenylmaleimide to furnish the new annelated carbazoles 4-10 in a one-pot process.In an analogous procedure, the in situ generated N-benzoylindole-2,3-quinodimethane (13) reacted with quinones to furnish the dioxocarbazoles 14-16.Compounds 4-8 and 14-16 with a coplanar skeleton are members of a class of potential DNA intercalators, as has been shown for 5 and 8 by X-ray structural analysis.On the basis of the geometries determined by X-ray crystallography, the intercalative binding of these molecules with a Watson-Crick mini-helix was predicted by molecular modeling methods. Key words: annelated carbazoles; crystal structures; molecular modeling; DNA intercalators.
View MoreShenyang Xingzhenghe Chemical Co., Ltd.
Contact:024-23509232
Address:No. 33, Naner Road, Heping Dist.
Frapp's Chemical (NFTZ) Co.,Ltd
Contact:+86-576-86137892
Address:General Chamber of Commercial Building, 159 Wanchang Middle Road, Wenling, Zhejiang, China
Contact:0086-22-23410962
Address:17-201, Ningfuli, Shuishanggongyuandong road,Nankai district, Tianjin, China
Contact:+86-535-8888888
Address:No.161 Haishi Rd.
Contact:+86-10-62651721
Address:29 Yongxing Road, Daxing District,Beijing China
Doi:10.1016/j.saa.2013.10.066
(2014)Doi:10.1021/acsmedchemlett.5b00402
(2016)Doi:10.1039/c1ob06038d
(2011)Doi:10.1016/S0040-4020(01)96113-7
(1991)Doi:10.1021/jo00053a056
(1993)Doi:10.1016/j.bmcl.2015.05.082
(2015)
