Monatshefte fur Chemie p. 559 - 576 (1993)
Update date:2022-07-29
Topics:
Draeger, M.
Haber, M.
Erfanian-Abdoust, H.
Pindur, U.
Sattler, Kristin
1-Alkylpyrano<3,4-b>indol-3-ones 3 react via a Diels-Alder step with an aryne or N-phenylmaleimide to furnish the new annelated carbazoles 4-10 in a one-pot process.In an analogous procedure, the in situ generated N-benzoylindole-2,3-quinodimethane (13) reacted with quinones to furnish the dioxocarbazoles 14-16.Compounds 4-8 and 14-16 with a coplanar skeleton are members of a class of potential DNA intercalators, as has been shown for 5 and 8 by X-ray structural analysis.On the basis of the geometries determined by X-ray crystallography, the intercalative binding of these molecules with a Watson-Crick mini-helix was predicted by molecular modeling methods. Key words: annelated carbazoles; crystal structures; molecular modeling; DNA intercalators.
View MoreJingzhou TianHe Sci&Tech Chemical Co., Ltd.
Contact:86-716-8331612
Address:Jiangjin Road, #18, High-grade technology industries development district, Jingzhou city, Hubei province
Contact:+86-10-67147360/67107388
Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China
Contact:0086-29-88315623
Address:S711, Innovation Bldg No.25 Gaoxin 1st Rd, Xian P.R of China 710075
Beijing Century Richap Chemistry Co.,Ltd
Contact:+86- 010-64455497
Address:Guannan County, Lianyungang City, Jiangsu Province, China
website:http://www.chinabarton.com
Contact:+86-573-82719618
Address:No. 162 Fumin Road, Honghe Town,
Doi:10.1016/j.saa.2013.10.066
(2014)Doi:10.1021/acsmedchemlett.5b00402
(2016)Doi:10.1039/c1ob06038d
(2011)Doi:10.1016/S0040-4020(01)96113-7
(1991)Doi:10.1021/jo00053a056
(1993)Doi:10.1016/j.bmcl.2015.05.082
(2015)
