Monatshefte fur Chemie p. 559 - 576 (1993)
Update date:2022-07-29
Topics:
Draeger, M.
Haber, M.
Erfanian-Abdoust, H.
Pindur, U.
Sattler, Kristin
1-Alkylpyrano<3,4-b>indol-3-ones 3 react via a Diels-Alder step with an aryne or N-phenylmaleimide to furnish the new annelated carbazoles 4-10 in a one-pot process.In an analogous procedure, the in situ generated N-benzoylindole-2,3-quinodimethane (13) reacted with quinones to furnish the dioxocarbazoles 14-16.Compounds 4-8 and 14-16 with a coplanar skeleton are members of a class of potential DNA intercalators, as has been shown for 5 and 8 by X-ray structural analysis.On the basis of the geometries determined by X-ray crystallography, the intercalative binding of these molecules with a Watson-Crick mini-helix was predicted by molecular modeling methods. Key words: annelated carbazoles; crystal structures; molecular modeling; DNA intercalators.
View MoreContact:0311-13263231263
Address:jian hua street,Shijiazhuang City, China
Guangzhou Swan Chemical Co., Ltd.
Contact:+86-20-31075659
Address:NO.301, Hong ba fang investment BLDG 1,Guan chong village,Shiqi town,Panyu district,Guangzhou
Zibo Fuxi'er Chemical Co.,Ltd （Shanxian Fuxi'er Chemical Co.,Ltd）
Contact:+86-533-2091422
Address:Eastern 4 on the 3th Road ,Liangxiang Industrial Park, Zibo city ,Shandong,China
Compro Shijiazhuang Fine Chemical Co., Ltd
Contact:0086-311-89689838
Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Nanjing Yuance Industry&Trade Co., Ltd.
website:http://www.njyuance.cn/
Contact:+86-25-85439097
Address:B1702, Aoti Bldg, No. 130, Aoti Avenue, Nanjing, China
Doi:10.1016/j.saa.2013.10.066
(2014)Doi:10.1021/acsmedchemlett.5b00402
(2016)Doi:10.1039/c1ob06038d
(2011)Doi:10.1016/S0040-4020(01)96113-7
(1991)Doi:10.1021/jo00053a056
(1993)Doi:10.1016/j.bmcl.2015.05.082
(2015)
