Kinetic resolution of racemic carboxylic acids with homochiral alcohols and dicyclohexylcarbodiimide

Article abstract of DOI:10.1016/S0957-4166(00)80527-3

Racemic carboxylic acids have been kinetically resolved by means of homochiral alcohols using the DCC-esterification methodology. The best results were obtained with commercially available homochiral 1-(4-pyridyl)ethanol: <60% e.e. for enantiomerically enriched acids and <76% d.e. for diastereomerically enriched esters.