Synthesis of (hetero)arylated pyridazin-3(2 H)-ones via Negishi reaction involving zincated pyridazin-3(2 H)-ones

Article abstract of DOI:10.1021/jo201587j

Zincated pyridazin-3(2H)-ones generated via bromine - magnesium exchange followed by transmetalation using ZnCl₂ or via lactam-directed ortho C4-H zincation with TMPZnCl·LiCl have been synthesized. These in situ created organometallics can be u