Medicinal Chemistry Research p. 523 - 530 (2012)
Update date:2022-09-26
Topics:
Ding, Rui
He, Yong
Xu, Jingli
Liu, Hang
Wang, Xiao
Feng, Man
Qi, Chuanmin
Zhang, Junbo
Peng, Cheng
The 7-(2-aminoethylamino)-5-methyl-3-cyanopyrazolo[ 1,5-a]pyrimidine (AMCPP) was synthesized and conjugated with N-mercaptoacetylglycine (MAG), N-mercaptoacetylphenylalanine (MAF), and N-mercaptoacetylvaline (MAA), respectively. These three compounds were labeled successfully with [ 99mTcN]2+ intermediate in high radiochemical purities. Biodistribution in tumor-bearing mice demonstrated that the three new complexes showed high tumor-to-muscle (T/M) ratios and rapid clearance from the blood, muscle, liver, kidney, and lung. Among them, the 99mTcN-MAG-AMCPP showed the most favorable characteristics. The tumor/blood and tumor/muscle ratios reached 1.50 and 1.15 at 30 min post-injection, 2.20 and 1.83 at 60 min post-injection. Springer Science+Business Media, LLC 2011.
View MoreShangHai Ruiyi Medical Technology Co.,Ltd.
Contact:+86-21-54718086
Address:No951 Jianchuan RD,Minhang District
website:http://www.maisonchem.com.cn
Contact:0086-311-83833777
Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
Wuxi Zuping Food Science And Technology Co.,LTD.
Contact:+86-510-87210822
Address:Guanlin town
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Changzhou Ruiping Chemical Co., Ltd
website:http://www.wishchem.com
Contact:+86-519-82324280
Address:No.288-1 Huacheng Road, Jintan
Doi:10.1016/j.jfluchem.2004.10.009
(2005)Doi:10.1039/c8dt00256h
(2018)Doi:10.1021/acs.orglett.8b03496
(2019)Doi:10.1016/j.bmcl.2014.08.047
(2014)Doi:10.1002/hlca.201100292
(2011)Doi:10.1021/ol402540g
(2013)