Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56(lck)

DOI: 10.1021/jm00056a001

Source and publish data:

Journal of Medicinal Chemistry p. 425 - 432 (1993)

Update date:2022-09-26

Topics:

Authors:

Burke Jr.

Lim Lim

Marquez Marquez

Bolen Bolen

Stefanova

Horak Horak

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Article abstract of DOI:10.1021/jm00056a001

A study was undertaken to prepare inhibitors of the lymphocyte protein- tyrosine kinase p56(lck). Using the known p56(lck) inhibitor 3,4-dihydroxy- α-cyanocinnamamide (4) as a lead compound, bicyclic analogues were designed as conformationally constrained

Full text of DOI:10.1021/jm00056a001

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