
Carbohydrate Research p. 21 - 28 (1988)
Update date:2022-08-03
Topics:
Herzig, Jacob
Nudelman, Abraham
Gottlieb, Hugo E.
A simple, regioselective O-deacetylation procedure is described which involves =0.5 equiv. of Bu3SnOMe or Bu2SnO in methanol.Anomeric acetates are considerably more reactive than primary and secondary acetates, thereby enabling selective removal, to give ca.70percent of products with HO-1 unsubstituted.Prolonged reaction resulted in complete deacetylation.Secondary acetates were removed faster than primary acetates and the overall rates of reaction were influenced greatly by the anomeric substituent in the order of OAc >> OH > OMe.No acyl migration took place under the reaction conditions.
View MoreBeijing Mediking Biopharm Co., Ltd.
Contact:+86-10-89753524/81760121/81769521
Address:Hongxianghong Incubator, Beiqijia Town, Changping district, Beijing, China
Nantong LiKai Chemical Co.,Ltd
Contact:+86-513-89068669
Address:Jincheng Science Park
LinHai Cina Chemical Co., LTD.
Contact:0576-85580989
Address:Pharma-chem zone,Duqiao,Linhai,Zhejiang,China
Disynthesis Chemical Technology Co. Ltd.
Contact:+86-571-88194596
Address:Dengyun road 380, Gongshu district, Hangzhou city, China
Xinchang Jiu Xin Pharmaceutical Co., Ltd
website:http://www.jiuxinpharm.com
Contact:86 137 5756 8585
Address:Poyang industry Park
Doi:10.1016/j.tetlet.2011.09.035
(2011)Doi:10.1016/j.bmc.2012.05.051
(2012)Doi:10.1039/c8ob00841h
(2018)Doi:10.1021/jo201988m
(2012)Doi:10.1134/S1070428020060147
(2020)Doi:10.1021/jm00112a039
(1991)