
Carbohydrate Research p. 21 - 28 (1988)
Update date:2022-08-03
Topics:
Herzig, Jacob
Nudelman, Abraham
Gottlieb, Hugo E.
A simple, regioselective O-deacetylation procedure is described which involves =0.5 equiv. of Bu3SnOMe or Bu2SnO in methanol.Anomeric acetates are considerably more reactive than primary and secondary acetates, thereby enabling selective removal, to give ca.70percent of products with HO-1 unsubstituted.Prolonged reaction resulted in complete deacetylation.Secondary acetates were removed faster than primary acetates and the overall rates of reaction were influenced greatly by the anomeric substituent in the order of OAc >> OH > OMe.No acyl migration took place under the reaction conditions.
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