NITROAZINES. 12. REACTION OF 6-NITROAZOLOPYRIMIDINES WITH ACETONITRILES

Article abstract of DOI:10.1007/BF00476759

Reaction of 6-nitroazolo<1,5-a>pyrimidines with cyanoacetamide, cyanoacetthioamide, or benzoylacetonitrile results in the conversion of the pyrimidine ring into a pyridine ring with the formation of 2-azolylamino-5-nitropyridines.Treatment of the latter with alcoholic sodium carbonate, or reaction of the azolopyrimidines with acetonitriles in an alkaline medium, affords 7-nitroazolo<1,5-a>pyrido<2,3-d>pyrimidines.