Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors

DOI: 10.1016/j.bmcl.2011.09.066

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 7185 - 7188 (2011)

Update date:2022-07-30

Topics:

Authors:

Ryu, Jae Wook

Han, Sun-Young

Yun, Jeong In

Choi, Sang-Un

Jung, Heejung

Ha, Jae Du

Cho, Sung Yun

Lee, Chong Ock

Kang, Nam Sook

Koh, Jong Sung

Kim, Hyoung Rae

Lee, Jongkook

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Article abstract of DOI:10.1016/j.bmcl.2011.09.066

A series of triazolopyridazines substituted with methylisoquinolinone were designed and synthesized. Some of the triazolopyridazines strongly inhibited c-Met kinase and showed good anti-proliferative activity against a panel of c-Met-amplified gastric cancer cell lines (MKN-45, SNU-5 and Hs746T).

Full text of DOI:10.1016/j.bmcl.2011.09.066

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