Tetrahedron p. 2207 - 2210 (1983)
Update date:2022-07-30
Topics:
Schneiderwind, Ruth G. K.
Ugi, Ivar
The protection of the heterocyclic groups of nucleosides by the 2,2,2-trichloro-t-butoxycarbonyl group (TCBOC) is described.This N-protecting group is sufficiently stable against the conditions used in oliginucleotide synthesis, and is selectively removed by cobalt(I) phthalocyanine at 0 deg C-20 deg C in neutral solution.
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