Direct Conversion of (1S,2S)-2-Amino-1--1,3-propanediol into Its Enantiomer for Efficient Synthesis of Thiamphenicol and Florfenicol

Article abstract of DOI:10.1021/jo00021a028

The usual synthesis of thiamphenicol and florfenicol involves the resolution of racemic threo-2-amino-1-<(4-methylthio)phenyl>-1,3-propanediol into its 1S,2S and 1R,2R isomers ((+)-3 and (-)-3), of which only the latter is a useful precursor.An efficient conversion of the 1S,2S isomer into the 1R,2R enantiomer in high yield, is described.