A NEW APPROACH FOR PREPARATION OF ATROPISOMERS OF ARYLPYRIDYLS VIA CROSS-COUPLING REACTIONS OF ARYL 2-(3-SUBSTITUTED)PYRIDYL SULFOXIDES WITH GRIGNARD AND ORGANOLITHIUM REAGENTS

Article abstract of DOI:10.1016/0040-4039(91)80656-Q

The cross-coupling reactions of phenyl 2-(3-substituted)pyridyl sulfoxides with 2-methoxyphenyl- and 1-(2-methoxy)naphthyl Grignard and 2-phenoxyphenyl lithium reagents afforded atropisomers of arylpyridyl derivatives in good yields which undergo thermal epimerization.