Triazolo[4,3-a]quinoline and tetrazolo[1,5-a]quinoline derivatives. Synthesis and pharmacological evaluation as platelets antiaggregating agents acting through phosphodiesterases inhibition

DOI: 10.1016/0223-5234(91)90028-L

Source and publish data:

European Journal of Medicinal Chemistry p. 189 - 196 (1991)

Update date:2022-08-04

Topics:

Authors:

Desos Desos

Schlewer

Lugnier Lugnier

Beretz Beretz

Maffrand

Bernat Bernat

Wermuth Wermuth

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Article abstract of DOI:10.1016/0223-5234(91)90028-L

The lactame-triazole or lactame-tetrazole isostery applied to the quinoline lactames of compound Y-590 or cilostazole lead to compounds which show similar potencies on platelet specific phosphodiesterase inhibition, platelet aggregation inhibition and ant

Full text of DOI:10.1016/0223-5234(91)90028-L

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