Triazolo[4,3-a]quinoline and tetrazolo[1,5-a]quinoline derivatives. Synthesis and pharmacological evaluation as platelets antiaggregating agents acting through phosphodiesterases inhibition

Article abstract of DOI:10.1016/0223-5234(91)90028-L

The lactame-triazole or lactame-tetrazole isostery applied to the quinoline lactames of compound Y-590 or cilostazole lead to compounds which show similar potencies on platelet specific phosphodiesterase inhibition, platelet aggregation inhibition and ant