Synthesis of Enantioenriched α-Hydroxy-α-allenylacetic Acids by Wittig Rearrangement of (Propargyloxy)acetates

DOI: 10.1021/jo00016a020

Source and publish data:

Journal of Organic Chemistry p. 4913 - 4918 (1991)

Update date:2022-08-04

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Authors:

Marshall, James A.

Wang, Xiao-jun

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Article abstract of DOI:10.1021/jo00016a020

Optically active (R)-(propargyloxy)acetic esters 5, available in ca. 90 percent ee through reduction of alkynones 2 with Chirald-LiAlH4 followed by alkylation with chloroacetic acid and esterification with CH2N2, undergo highly stereoselective <2,3> rearr

Full text of DOI:10.1021/jo00016a020

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