A convenient preparation of 8-ethyl-4,9-dihydro-3H-pyrano[3,4-b]indole-1-one, key intermediate of the antiinflammatory agent Etodolac

Article abstract of DOI:10.1080/00397919108020835

A facile synthesis of 8-ethyl-4,9-dihydro-3H-pyrano[3,4-b]indole-1-one 5 is described which features the condensation of hydrazines with 2-oxo-5-hydroxypentanoic acid, followed by Fischer cyclization of these adducts.

Full text of DOI:10.1080/00397919108020835

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Synthetic Communications: An
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A Convenient Preparation
of 8-Ethyl-4,9-dihydro-3H-
pyrano[3,4-b]indole-1-one,
Key Intermediate of the
Antiinflammatory Agent
Etodolac
Asensio González a
a Laboratory of Organic Chemistry, Faculty of
Pharmacy , University of Barcelona , 08028,
Barcelona, Spain
Published online: 23 Sep 2006.
To cite this article: Asensio González (1991) A Convenient Preparation of 8-
Ethyl-4,9-dihydro-3H-pyrano[3,4-b]indole-1-one, Key Intermediate of the
Antiinflammatory Agent Etodolac, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 21:5, 669-674, DOI:
10.1080/00397919108020835
To link to this article: http://dx.doi.org/10.1080/00397919108020835
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