Highly selective TFAA-cleavage of tertiary 2,4-dimethoxybenzylamines and its use in the synthesis of secondary amines

Article abstract of DOI:10.1016/S0040-4020(01)86465-6

TFAA-treatment of allylic, propargylic, homopropargylic and some benzylic tert. 2, 4-dimethoxybenzylamines leads to highly selective cleavage of their dimethoxybenzylic C-N bonds. The resultant trifluoroacetamides can then readily be converted to the corresponding secondary amines.