Highly selective TFAA-cleavage of tertiary 2,4-dimethoxybenzylamines and its use in the synthesis of secondary amines

DOI: 10.1016/S0040-4020(01)86465-6

Source and publish data:

Tetrahedron p. 4591 - 4602 (1991)

Update date:2022-08-04

Topics:

Authors:

Nussbaumer

Baumann Baumann

Dechat Dechat

Harasek Harasek

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Article abstract of DOI:10.1016/S0040-4020(01)86465-6

TFAA-treatment of allylic, propargylic, homopropargylic and some benzylic tert. 2, 4-dimethoxybenzylamines leads to highly selective cleavage of their dimethoxybenzylic C-N bonds. The resultant trifluoroacetamides can then readily be converted to the corresponding secondary amines.

Full text of DOI:10.1016/S0040-4020(01)86465-6

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