Journal of Organic Chemistry p. 6336 - 6341 (2015)
Update date:2022-07-29
Topics:
Lippur, Kristin
Kaabel, Sandra
J?rving, Ivar
Rissanen, Kari
Kanger, T?nis
A mild protocol for the asymmetric Michael addition of dimethyl malonate to various α,β-unsaturated carbonyl compounds was developed. The salient feature of this methodology is that a cheap and environmentally friendly Lewis acid, CaCl2, was used as a catalyst. An aminoindanol- and pyridine-derived ligand provided in the presence of CaCl2 Michael adducts in moderate to high enantioselectivities. The scope of the reaction was demonstrated.
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