Journal of Medicinal Chemistry p. 3771 - 3783 (1993)
Update date:2022-09-26
Topics: Inhibitors Derivatives Substituted Structure-based design
Erion, Mark D.
Niwas, Shri
Rose, Jerry D.
Ananthan, Subramaniam
Allen, Mark
et al.
X-ray crystallography and computer-assisted molecular modeling (CAMM) studies aided in the design of a potent series of Mammalian purine nucleoside phosphorylase (PNP) inhibitors.Enhanced potency was achieved by designing substituted 9-(arylmethyl)-9-deaz
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