Synthesis of a 2,4-diaminodihydrohomopteridine, 6-acetyl-2,4-diamino-7,8-dihydro-9H-pyrimido[4,5-b][1,4]diazepine, using a furazano[3,4-d]pyrimidine precursor

Article abstract of DOI:10.1016/S0040-4020(01)87137-4

5-Amino-7-(methylthio)furazano[3,4-d]pyrimidine (3) reacts readily with a variety of amines and hydroxylamines under mild conditions, with the introduction of an N-substituent at position 7. Using this reaction of (3) with 1-amino-4,4-diethoxy-3-pentanol