The Use of the β-Amino-Alcohol-N-Oxide Derivatives in the Synthesis of 2,3 or 4-Alkyl Substituted NH Pyrrolidines

Article abstract of DOI:10.1016/S0040-4020(01)87128-3

Nonstabilized azomethine ylides generated from the various β-amino alcohols N-oxides 13, 17, 23 and 24 undergo <3+2> cycloaddition reactions with unactivated alkenes to afford the corresponding pyrrolidines 14a-g, 18a-g, 25 und 27 in moderate to good yields.These compounds are precursors of NH pyrrolidines substituted in position 2, 3 or 4.