A novel synthesis of 1-aminoalkylphosphonates

Article abstract of DOI:10.1080/00397919108019793

A novel route has been devised for the preparation of a series of 1-aminoalkylphosphonate diesters, precursors to analogues of a-amino acids. The route involves a facile bromine substitution at the 1-position of alkylphosphonate diesters using N-bromosuccinimide, followed by azide ion displacement and catalytic hydrogenolysis.

Full text of DOI:10.1080/00397919108019793

This article was downloaded by: [University of Glasgow]
On: 10 October 2014, At: 05:25
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH,
UK
Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
A Novel Synthesis of 1-
Aminoalkylphosphonates
Subir K. Chakraborty a & Robert Engel a
a Department of Chemistry and Biochemistry ,
Queens College of the City University of New York ,
Flushing, New York, 11367, U.S.A.
Published online: 23 Sep 2006.
To cite this article: Subir K. Chakraborty & Robert Engel (1991) A Novel Synthesis
of 1-Aminoalkylphosphonates, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 21:8-9, 1039-1046, DOI:
10.1080/00397919108019793
To link to this article: http://dx.doi.org/10.1080/00397919108019793
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the
information (the “Content”) contained in the publications on our platform.
However, Taylor & Francis, our agents, and our licensors make no
representations or warranties whatsoever as to the accuracy, completeness,
or suitability for any purpose of the Content. Any opinions and views
expressed in this publication are the opinions and views of the authors, and
are not the views of or endorsed by Taylor & Francis. The accuracy of the
Content should not be relied upon and should be independently verified with
primary sources of information. Taylor and Francis shall not be liable for any
losses, actions, claims, proceedings, demands, costs, expenses, damages,
and other liabilities whatsoever or howsoever caused arising directly or

indirectly in connection with, in relation to or arising out of the use of the
Content.
This article may be used for research, teaching, and private study purposes.
Any substantial or systematic reproduction, redistribution, reselling, loan,
sub-licensing, systematic supply, or distribution in any form to anyone is
expressly forbidden. Terms & Conditions of access and use can be found at
http://www.tandfonline.com/page/terms-and-conditions