First synthesis of [6-15N]-cladribine using ribonucleoside as a starting material

Article abstract of DOI:10.3987/COM-11-12382

We have synthesized two types of [6-15N]-deoxyadenosine analogs: [6-15N]-2'-deoxyadenosine (1) and [6-15N]-2-chloro-2'-deoxyadenosine ([6-15N]-cladribine, 2), which utilized the readily available ribonucleosides inosine and guanosine, respectively, via 3'-benzoyl-5'-trityl- (or tert-butyldimethylsilyl)-substituted intermediates (6, 15).