C-X (X=Br, I) bond-tolerant aerobic oxidative cross-coupling: A strategy to selectively construct β-aryl ketones and aldehydes

Article abstract of DOI:10.1002/adsc.201100782

Using moelcular oxygen as the terminal oxidant, various aryl halide-containing β-aryl ketones and aldehydes can be synthesized directly from readily available allyic alcohols and boronic acids via palladium-catalyzed oxidative cross-coupling reactions. The dual roles of copper, including electron-carrier and Lewis acid functions, are supposed to be critical for the high reactivity and selectivity of this aerobic oxidative coupling transformation. Copyright