Journal of Fluorine Chemistry p. 354 - 357 (2012)
Update date:2022-08-03
Topics:
Wei, Lulin
Makowski, Teresa M.
Rutherford, Jennifer L.
A facile and fluorination-free synthesis of 3,3-difluoropyrrolidine hydrochloride (3), an important synthon in the synthesis of biologically active compounds, is reported. The seven-step synthesis starts from the commercially available 2-chloro-2,2-difluoroacetic acid (1) in a three-step telescoped process that produces crystalline N,N-diethyl-2,2-difluoro-3-hydroxy-4- nitrobutanamide (2). A convenient and high-yielding reductive nitromethylation of 2 followed by a catalytic hydrogenation/cyclization sequence and borane reduction affords 3 in good yield and purity.
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Doi:10.1002/chir.22540
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(1991)Doi:10.1021/om2012216
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(2012)