Alternative two-step route to khellactone analogues using silica tungstic acid and sodium hydrogen phosphate

Article abstract of DOI:10.2478/s11696-013-0411-z

A series of coumarins was synthesised via the silica tungstic acid-catalysed Pechmann reaction; some of these were employed for known three-component reactions with aromatic aldehydes and malononitrile in the presence of sodium hydrogen phosphate (Na₂HPO₄) as a basic catalyst, affording a variety of potentially anti-HIV active khellactone analogues.