Journal of Antibiotics p. 1336 - 1344 (1995)
Update date:2022-09-26
Topics: Synthesis in vivo Biological Activity pseudomonic acid heterocyclyl substituted oxazole derivatives
Broom
Elder
Hannan
Pons
O'Hanlon
Walker
Wilson
Woodall
Semisynthetic analogues of pseudomonic acid A have been prepared containing a heterocyclyl substituted oxazole. Derivatives in which the heterocycle was thiophene, furan, pyridine, or isoxazole showed good antibacterial potency and were further evaluated in vivo. Both pharmacokinetic parameters and oral activity against an experimental intraperitoneal sepsis were superior to results obtained from previously described pseudomonic acid A derivatives.
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