Polysubstituted piperidines via iodolactonization: Application to the asymmetric synthesis of (+)-pseudodistomin D

Article abstract of DOI:10.1021/ol300209s

Conjugate addition of lithium (S)-N-allyl-N-(α-methyl-p- methoxybenzyl)amide to methyl (E,E)-hepta-2,5-dienoate furnished the corresponding β-amino ester. N-Protecting group manipulation, ring-closing metathesis, and ester hydrolysis gave enantiopure [N(1