Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [11C-carbonyl] AR-A014418 by [11C] CO2 fixation

DOI: 10.1016/j.bmcl.2011.12.139

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2099 - 2101 (2012)

Update date:2022-09-26

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Authors:

Hicks, Justin W.

Wilson, Alan A.

Rubie, Elizabeth A.

Woodgett, James R.

Houle, Sylvain

Vasdev, Neil

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Article abstract of DOI:10.1016/j.bmcl.2011.12.139

The highly selective glycogen synthase kinase-3 (GSK-3) inhibitor N-(4-methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea (AR-A014418) was radiolabeled with carbon-11 (¹¹C; half-life = 20.4 min) at the urea moiety via [¹¹C]CO_{2
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Full text of DOI:10.1016/j.bmcl.2011.12.139

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