Benzo[a]pyrene anti-diol epoxide covalently modifies human serum albumin carboxylate side chains and imidazole side chain of histidine(146)

Article abstract of DOI:10.1021/ja00022a044

Human serum albumin was reacted with (±)-r-7,t-8-dihydroxy-r-9,t-10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BaPDE) in vitro and extracted to remove byproducts not covalently bound to the protein. Enzymatic digestion of the adducted protein in H