Chemical and Pharmaceutical Bulletin p. 1430 - 1435 (1991)
Update date:2022-07-29
Topics:
Ueda
Ishii
Sinozaki
Seiki
Hatanaka
N-[3-{3-(Piperidinomethyl)phenoxy}propyl]butamides having a 1-methyl-1H-tetrazol-5-ylthio moiety as a pharmacophore and related compounds were prepared and tested for their antisecretory activity against histamine-induced gastric acid secretion in conscious rats with gastric fistulas. Most of the compounds showed antisecretory activity. Among them, N-[3-{3-(piperidinomethyl)phenoxy}propyl]-4-(1-methyl-1H-tetrazol-5- ylthio)butanamide (5f) was found to possess the most potent activity, and a possibility of isosteric replacement of the methoxycarbonyl group with 1-methyl-1H-tetrazol-5-yl group was indicated. The structure-activity relationships are also discussed.
View MoreChengdu Baishixing Science and Technology Industry Co., Ltd.
website:http://www.cd-bsx.com
Contact:+86-28-88531548
Address:#217,North of Industry Road,Heshan Town,Pujiang County,Chengdu,Sichuan,China.
Zhejiang Kangfeng Chemical Co.,LTD.
Contact:+86-579-86709687
Address:Xueshizhai Industrial Zone, Weishan Town,Dongyang City, Zhejiang Province ,China
Guangzhou Reachin Chemical Co., Ltd
Contact:+86-20-37087379 ext.604
Address:A122C-1, Tianyuan Plaza, 401 Tianyuan Rd., Tianhe, Guangzhou, China
Jiangxi Global Natural Spice Co., Ltd.
website:https://www.jxhqxl.com/
Contact:+86-796-8106598
Address:No.89, Wenshan Road,South Industrial Park, Jishui County,Jiangxi Province
Contact:+1-284-4950244
Address:Box 3069, Road Town, Tortola, British Virgin Islands
Doi:10.1016/j.tetlet.2012.01.036
(2012)Doi:10.1021/ja052804q
(2005)Doi:10.1016/S0040-4039(00)79876-5
(1991)Doi:10.1021/jo300205b
(2012)Doi:10.1021/acs.jmedchem.1c00408
(2021)Doi:10.1248/cpb.59.1509
(2011)
