Dual Lewis acid-Lewis base activation in enantioselective cyanation of aldehydes using acetyl cyanide and cyanoformate as cyanide sources

DOI: 10.1021/ja052804q

Source and publish data:

Journal of the American Chemical Society p. 11592 - 11593 (2005)

Update date:2022-07-29

Topics:

Authors:

Lundgren, Stina

Wingstrand, Erica

Penhoat, Mael

Moberg, Christina

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/ja052804q

Dual activation by a chiral Lewis acid and an achiral or chiral Lewis base enabled cyanation of both aromatic and aliphatic aldehydes with acetyl cyanide and ethyl cyanoformate to provide direct access to O-acetylated and O-alkoxycarbonylated cyanohydrins

Full text of DOI:10.1021/ja052804q

Products guided by the article

Product name:(S)-2-acetyloxy-2-(4-methylphenyl)acetonitrile

Cas No:136983-96-5

R&D Labs maybe for 136983-96-5

Chengdu Boon Stream Chemical Industry Co.,Ltd.

Contact:+86-28-83156758

Address:No.859,Dongzikou Road,Jinniu District,Chengdu,Sichuan,P.R.China
Jiaozuo Zhongwen Trading Coporation Limited

Contact:--

Address:East Renmin Road
Shanghai Pengkai Chemical Co.,Ltd

Contact:+86-21-60526671

Address:No.4226 Duzhuang Rd Minhang District Shanghai China
Ji'nan Orgachem Pharmaceutical Co.,Ltd

Contact:+86-531-82687810

Address:Jinan
Anhui Dexinjia Biopharm Co., Ltd

Contact:+86-531-82375818

Address:9 Hexie Road, kaifaqu, Taihe

Relevant to this article

Synthesis and antimicrobial activity of pyrrolyl/pyrazolyl arylaminosulfonylmethyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles

Doi:10.1248/cpb.59.1509
(2011)
Highly enantioselective synthesis of 2,3-dihydroquinazolinones through intramolecular amidation of imines

Doi:10.1021/ol300518m
(2012)
Enantioselective synthesis of dihydroquinazolinone derivatives catalyzed by a chiral organocatalyst

Doi:10.1039/c7nj00538e
(2017)
Synthesis of novel optically pure α-amino acid functionalised-7- trifluoromethyl substituted quinolone derivatives and their antibacterial activity

Doi:10.1007/s00044-012-0020-3
(2013)
Anti-cancer, anti-oxidant and molecular docking studies of thiosemicarbazone indole-based derivatives

Doi:10.1007/s11164-019-03765-9
(2019)
Orthogonal Strapping of o-Haloaryl Ynones with Pyrazolones: A One-Pot, Domino Process toward Spiropyrazolones

Doi:10.1021/acs.joc.0c02087
(2020)

Article Doi