Heteroatom Analogues of Bemoradan: Chemistry and Cardiotonic Activity of 1,4-Benzothiazinylpyridazinones

Article abstract of DOI:10.1021/jm00079a023

A series of close analogues of the potent, long-acting cardiotonic bemoradan (2a) was synthesized and examined in both in vitro and in vivo test systems.Changing the oxygen heteroatom at the 1-position of the benzoxazine ring of bemoradan to sulfur gave 4