Heteroatom Analogues of Bemoradan: Chemistry and Cardiotonic Activity of 1,4-Benzothiazinylpyridazinones

DOI: 10.1021/jm00079a023

Source and publish data:

Journal of Medicinal Chemistry p. 172 - 176 (1992)

Update date:2022-07-30

Topics:

Authors:

Combs, Donald W.

Rampulla, Marianne S.

Demers, James P.

Falotico, Robert

Moore, John B.

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Article abstract of DOI:10.1021/jm00079a023

A series of close analogues of the potent, long-acting cardiotonic bemoradan (2a) was synthesized and examined in both in vitro and in vivo test systems.Changing the oxygen heteroatom at the 1-position of the benzoxazine ring of bemoradan to sulfur gave 4

Full text of DOI:10.1021/jm00079a023

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