Tetrahedron Asymmetry p. 705 - 720 (1991)
Update date:2022-07-30
Topics:
Moorlag
Kellogg
The enzymatic hydrolyses of a variety of α-substituted mandelic and lactic esters using pig liver esterase (PLE) have been investigated. High to moderate enantioselectivity was found for various α-substituted mandelic esters, whereas PLE showed low to no enantioselectivity for α-substituted lactic esters. We observed that the enantioselectivity of PLE depends strongly on the length and nature of the substituent at the α-position. Some sequences for an active site model of PLE are discussed.
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Doi:10.1007/s11164-013-1483-7
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(2012)
