A chemoenzymatic synthesis of optically-active dihydropyridines

DOI: 10.1016/0040-4039(91)80807-I

Source and publish data:

Tetrahedron Letters p. 3465 - 3468 (1991)

Update date:2022-08-05

Topics:

Authors:

Holdgruen, Xenia K.

Sih, Charles J.

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Article abstract of DOI:10.1016/0040-4039(91)80807-I

A biocatalytic asymmetric synthesis of optically-active dihydropyridines has been developed. The method entails the enantiotopically-selective solvolysis of the sterically unhindered ester 13 in n-BuOH/H₂O catalyzed by Pseudomonas lipases.

Full text of DOI:10.1016/0040-4039(91)80807-I

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Product name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(phenylmethyl)-

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