New chiral phospholanes; synthesis, characterization, and use in asymmetric hydrogenation reactions

Article abstract of DOI:10.1016/S0957-4166(00)86109-1

We describe the practical synthesis of enantiomerically pure trans-2,5-disubstituted-1-phenylphospholanes which are then employed in the preparation of a new series of C₂-symmetric bis- and C₃-symmetric tris(phospholane) ligands. A versatile three-step route to the important chiral 1,4-diol intermediates, used in the phosphine syntheses, is outlined. Rhodium complexes bearing the new phosphine ligands were prepared and shown to act as efficient catalyst precursors for the enantioselective hydrogenation of various unsaturated substrates.