Russian Journal of General Chemistry p. 2643 - 2647 (2017)
Update date:2022-07-29
Topics:
Liang
Guo
Jiang
Istaroxime 1, a novel cardiotonic agent with high efficiency and low toxicity was synthesized from dehydroepiandrosterone 2 using a novel approach that included epoxidation, ring-opening, substitution, and oximation. The new protocol without gas protection was milder than the reported approaches. The overall yield of the method was 24.1%.
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