For-Met-ΔZLeu-Phe-OMe: A NEW ACTIVE ANALOG OF CHEMOTACTIC N-FORMYLTRIPEPTIDES WITH β-TURN CRYSTAL CONFORMATION

DOI: 10.1016/S0040-4039(00)92174-9

Source and publish data:

Tetrahedron Letters p. 4375 - 4376 (1991)

Update date:2022-08-04

Topics:

Authors:

Zecchini, Giampiero Pagani

Paradisi, Mario Paglialunga

Torrini, Ines

Lucente, Gino

Gavuzzo, Enrico

et al. et al.

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Article abstract of DOI:10.1016/S0040-4039(00)92174-9

The title Δ^ZLeu containing N-formyltripeptide 2, has been synthesized and found active in the superoxide production whereas inactive in the stimulation of human neutrophil migration.The X-ray crystallographic analysis reveals that 2 adopts a β-turn conformation stabilized by an intramolecular H-bond.

Full text of DOI:10.1016/S0040-4039(00)92174-9

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