Asymmetric Michael Addition of the N-Alkylidene Derivative of an α-Amino Ester to Methyl (E)-3-imidazol-3-yl>propenoate

Article abstract of DOI:10.1246/bcsj.64.2739

The exclusively diastereoselective asymmetric Michael addition of the lithiated methyl N-(2,2-dimethylpropylidene)glycinate to methyl (E)-3-<3R,7aS)-2-phenylperhydropyrrolo<1,2-c>imidazol-3-yl>propenoate is described.The synperiplanar conformer of the acc