Highly enantioselective and diastereoselective synthesis of β-amino acid esters and β-lactams from achiral esters and imines

Article abstract of DOI:10.1016/S0040-4039(00)92366-9

The reaction of S-tert-butyl thiopropionate with a number of N-benzyl or N-allyl aldimines (4) as promoted by the chiral diazaborolidine 1 and triethylamine afforded the β-amino acid esters 5 with high diastereoselectivity and enantioselectivity, providin