Tetrahedron Letters p. 6081 - 6084 (1991)
Update date:2022-07-30
Topics: Regioselectivity Yield NMR spectroscopy Stereochemistry Stereoselective synthesis Purification Catalysis Steroids Isotopic Labeling Pd-Catalyzed Synthetic Methodology Deuterium (D)
Rabinowitz
A simple and highly stereoselective synthesis of [4α-2H]- and [4α-3H]-Δ5-3β-hydroxysteroids is presented. Palladium(O)-mediated borodeuteride reduction of readily-available cholest-5-en-3β,4β-diol cyclic carbonate provides [4α-2H]-Δ5-and Δ4-cholesterol in a 12:1 ratio. Reduction of [4α-3H]-cholest-5-ene-3β,4β-diol cyclic carbonate with NaB1H4 and Pd(O) resulted in [4β-3H]-cholesterol.
View MoreWeifang Dongxing Chitosan Factory
website:http://dxchitosan.lookchem.com/
Contact:13475651157
Address:Weifang city ,shandong province
Changsha Goomoo Chemical Technology Co.Ltd
Contact:+86-731-82197655
Address:No.649,Chezhan Rd.(N),Changsha,Hunan,China
Zhejiang Golden-Shell Pharmaceutical Co.,Ltd.
Contact:+86-576-87501888 / 87501988
Address:No.89 Zhongxing Road. Li'ao, Yuhuan, Zhejiang, China
Hangzhou Haiqiang Chemical Co.,Ltd.
Contact:+86-571-86960370
Address:Add: 5/F, Around Town North Road,No. 10, Hangzhou, Zhejiang,China
Contact:+31-24-3886056
Address:Binderskampweg 29 Unit 36
Doi:10.1016/j.tetasy.2012.04.008
(2012)Doi:10.1021/jo3007732
(2012)Doi:10.1002/anie.201200447
(2012)Doi:10.1002/ejoc.201200107
(2012)Doi:10.1021/ja409861s
(2013)Doi:10.1021/ol3012056
(2012)
