Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors

DOI: 10.1016/j.bmc.2014.06.029

Source and publish data:

Bioorganic and Medicinal Chemistry p. 3850 - 3855 (2014)

Update date:2022-07-30

Topics:

Authors:

Hoque, Md. Ashraful

Islam, Md. Nurul

Islam, Md. Shahidul

Kato, Tamaki

Nishino, Norikazu

Ito, Akihiro

Yoshida, Minoru

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.bmc.2014.06.029

The naturally occurring cyclic depsipeptide, FK228 inhibits histone deacetylase (HDAC) enzymes after reductive cleavage of intra-molecular disulfide bond. One of the sulfhydryl groups produced in the reduction interacts with zinc atom that involved in the

Full text of DOI:10.1016/j.bmc.2014.06.029

Products guided by the article

Product name:C₂₂H₃₂N₂O₅

Cas No:1380236-70-3

R&D Labs maybe for 1380236-70-3

Hubei Sibo Technology Co.,Ltd.

Contact:0715-6597222

Address:Pan Jia Wan fan Lake Chemical Industrial Park ,Xianning City, Hubei, China
Jiangsu Seed Chem Co.,Ltd.

Contact:86-513-84128750/13773795976

Address:No.48.Youyi West Road ,Rudong Development Zone,Jiangsu Province,China
HAINAN JINYING IMPORT AND EXPORT CO. LTD

Contact:+86-898-32875423

Address:A SECTION 19TH FL, TIMES SQUARE, NO.2 GUO MAO AVENUE HAIKOU, HAINAN, P. R. OF CHINA
Shijiazhuang Frontierchem Co., Ltd.

Contact:+86-311-89271196

Address:4-4-202 No.15 Biandian Street,Shijiazhuang
Lanzhou huibang biological chemical technology Co., LTD

Contact:0931-7843964

Address:NO.2011,Yannan Road,Chengguan,

Relevant to this article

Facile synthesis of 2,3-disubstituted benzofurans via DBU-promoted intramolecular annulation of ortho oxyether aroylformates

Doi:10.1080/00397911.2018.1533973
(2018)
Reactivity of Ferrocenyl Phosphates Bearing (Hetero-)Aromatics and [3]Ferrocenophanes toward Anionic Phospho-Fries Rearrangements

Doi:10.1021/acs.joc.7b00030
(2017)
Doi:10.1021/ja00988a062
(1967)
Synthesis and characterization of {2,6-bis[(dimethylamino)methyl]phenyl}tin(II) chloride and {2,6-bis[(dimethylamino)methyl]phenyl}4-tolyltin(II), the first example of a mixed diaryltin(II) compound

Doi:10.1021/om00107a038
(1989)
Imidazo[1,2-a]pyridines susceptible to excited state intramolecular proton transfer: One-pot synthesis via an Ortoleva-King reaction

Doi:10.1021/jo300643w
(2012)
Highly enantioselective chlorination of β-keto esters and subsequent S_N2 displacement of tertiary chlorides: A flexible method for the construction of quaternary stereogenic centers

Doi:10.1021/ja304806j
(2012)

Article Doi