β-Diethoxyphosphorylpropionic acid, a convenient reagent for the synthesis of β,δ - unsaturated amides

Article abstract of DOI:10.1016/0040-4039(91)80796-9

β-Diethoxyphosphorylpropionic acid (1) is converted into δ-substituted β-(diethoxyphosphoryl)-δ-lactones 5 by LDA promoted reaction with carbonyl compounds 3. Aminolysis or alternatively a standard alkylation and aminolysis of 5 afford (E)- β,δ-imsaturated amides 7 or 10 in good yield.