Nucleophilic difluoromethylation of C=N bonds in heterocycles with difluoromethyl silane reagents

DOI: 10.1016/j.tet.2012.04.039

Source and publish data:

Tetrahedron p. 5137 - 5144 (2012)

Update date:2022-08-05

Topics:

Authors:

Huang, Weizhou

Ni, Chuanfa

Zhao, Yanchuan

Zhang, Wei

Dilman, Alexander D.

Hu, Jinbo

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Article abstract of DOI:10.1016/j.tet.2012.04.039

An efficient and straightforward nucleophilic difluoromethylation of CN bonds in heterocycles under the activation of alkylating agents has been developed. Cyclic iminium salts derived from dihydroisoquinolines, quinolines, and pyridines were successfully

Full text of DOI:10.1016/j.tet.2012.04.039

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