Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans Δ24-sterol methyltransferase

Article abstract of DOI:10.1021/jm00079a012

A series of side chain modified analogues of cholesterol and lanosterol (1-10) have been synthesized and evaluated as inhibitors of the Candida albicans Δ²⁴-sterol methyltransferase. Two sterol substrate analogues 1 and 2 which contained a 24-t