Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans Δ24-sterol methyltransferase

DOI: 10.1021/jm00079a012

Source and publish data:

Journal of Medicinal Chemistry p. 100 - 106 (1992)

Update date:2022-07-29

Topics:

Authors:

Ator, Mark A.

Schmidt, Stanley J.

Adams, Jerry L.

Dolle, Roland E.

Kruse, Lawrence I.

Frey, Carrie L.

Barone, Janice M.

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Article abstract of DOI:10.1021/jm00079a012

A series of side chain modified analogues of cholesterol and lanosterol (1-10) have been synthesized and evaluated as inhibitors of the Candida albicans Δ²⁴-sterol methyltransferase. Two sterol substrate analogues 1 and 2 which contained a 24-t

Full text of DOI:10.1021/jm00079a012

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