Enzyme-Catalyzed Formation of Chiral Monosubstituted Mixed Diesters and Half Esters of Malonic Acid in Organic Solvents

Article abstract of DOI:10.1021/jo00030a004

Enzymes in organic solvents were used to develop a strategy for the formation of heretofore unknown chiral monosubstituted malonate diesters and half esters.This enzymatic approach is not feasible in aqueous solutions because the activated malonic hydrogen invariably undergoes fast exchange accompanied by racemization.