Synthetic routes to ninhydrins. Preparation of ninhydrin, 5-methoxyninhydrin, and 5-(methylthio)ninhydrin

Article abstract of DOI:10.1080/00397919108055457

Two syntheses of 5-methoxyninhydrin (2,2-dihydroxy-5-methoxy-1,3-indanedione) are described. One method employs a novel and efficient two step route, which begins with commercially available 6-methoxy-1-indanone. The application of this strategy for the preparation of a new ninhydrin derivative, 5-(methylthio)ninhydrin, and ninhydrin is also presented.

Full text of DOI:10.1080/00397919108055457

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Synthetic Communications: An
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Synthetic Routes to Ninhydrins.
Preparation of Ninhydrin, 5-
Methoxyninhydrin, and 5-
(Methylthio)Ninhydrin
Robert J. Heffner a & Madeleine M. Joullié a
a Department of Chemistry , University of
Pennsylvania , Philadelphia, PA, 19104-6323
Published online: 18 Nov 2011.
To cite this article: Robert J. Heffner & Madeleine M. Joullié (1991) Synthetic
Routes to Ninhydrins. Preparation of Ninhydrin, 5-Methoxyninhydrin, and 5-
(Methylthio)Ninhydrin, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 21:21, 2231-2256, DOI:
10.1080/00397919108055457
To link to this article: http://dx.doi.org/10.1080/00397919108055457
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