Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles

DOI: 10.1016/j.bmcl.2012.05.055

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4820 - 4826 (2012)

Update date:2022-07-30

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Authors:

Mandadapu, Sivakoteswara Rao

Weerawarna, Pathum M.

Gunnam, Mallikarjuna Reddy

Alliston, Kevin R.

Lushington, Gerald H.

Kim, Yunjeong

Chang, Kyeong-Ok

Groutas, William C.

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Article abstract of DOI:10.1016/j.bmcl.2012.05.055

Series of structurally-diverse α-ketoamides and α- ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against Norwalk virus 3C protease in vitro, as well as anti-norovirus activity in a cell-based replicon system.

Full text of DOI:10.1016/j.bmcl.2012.05.055

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