Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic - Salinomycin

Article abstract of DOI:10.1016/j.bmcl.2012.05.081

For the first time a direct and practical approach to the synthesis of eight amide derivatives of polyether antibiotic - salinomycin is described. The structure of allyl amide (3a) has been determined using X-ray diffraction. Salinomycin and its amide der