Ring transformation with bridged 1,3-dicarbonyl heteroanalogues, III. 5-(ω-aminoalkyl)-1,2,4-oxadiazoles by ring-transformations of 3-methylthio-2-aza-3-propeniminium salts

Article abstract of DOI:10.1002/ardp.2503241205

3-Methylthio-2-aza-3-propeniminium salts 5 react with hydroxylamine after ring transformation under formation of 5-(ω-aminoalkyl)-1,2,4-oxadiazole hydroiodides 4·HI, which show a remarkable antitussive activity.