1,2-diastereoselection induced by chiral silicon in the addition of Grignard reagents to acylsilanes

Article abstract of DOI:10.1016/S0040-4039(00)93607-4

The reaction of acylsilanes 1 with Grignard reagents gives the diastereomeric α-hydroxysilanes 3. The level of asymmetric induction depends on the nature of R¹ and R². Good results were obtained for R¹=t-Bu, R²=